研究業績　2006.2.8現在

原著論文

  1. T. Maruyama, S. Sonokawa, H. Matsushita and M. Goto, Inhibitiory effects of gold(III) ions on ribonuclease and deoxyribonuclease. J Inorg. Biochem. in press.
  2. T. Maruyama, C. Komatsu, J. Michizoe, S. Sakai and M. Goto, Laccase-mediated degradation and reduction of toxicity of the postharvest fungicide imazalil. Process Biochem. In press.
  3. K Nakashima, J Okada, T. Maruyama, N Kamiya, M Goto, Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol). Sci Technol Adv Mater in press.
  4. K Nakashima, T. Maruyama, N Kamiya, M Goto, Homogeneous Enzymatic Reaction in Ionic Liquids with Poly(ethylene glycol)-Modified Subtilisin. Org. Biomol Chem 4, 3462?3467 (2006).
  5. T. Maruyama, T. Shinohara, T. Hosoki, H. Ichinose, N. Kamiya and M. Goto, Masking oligonucleotides improve sensitivity of mutation detection based on guanine quenching. Anal Biochem in press.
  6. T. Maruyama, C. Komatsu, J. Michizoe, H. Ichinose and M. Goto, Laccase-mediated oxidative degradation of the herbicide dymron. Biotechnol Prog, 22, 426-430 (2006).
  7. K. Nakashima, T. Maruyama, N. Kamiya, M. Goto, Comb-shaped poly(ethylene glycol)-modified subtilisin Carlsberg is soluble and highly active in ionic liquids. Chem. Commun. 4297-4299 (2005).
  8. T. Maruyama, T. Shinohara, H. Ichinose, M. Kitaoka, N Okamura, N. Kamiya, M. Goto, Mutation detection in DNA oligonucleotides based on a guanine quenching method coupled with enzymatic digestion of single-stranded DNA. Biotechnol. Lett. 27, 1349-1354 (2005).
  9. Ichinose, H; Kitaoka, M; Okamura, N; Maruyama, T; Kamiya, N; Goto, M. Detection of Single-Base Mutations by Fluorogenic Ribonuclease Protection Assay. Anal Chem, 77, 7047-7053 (2005).
  10. J. Tominaga, N. Kamiya, S. Doi, H. Ichinose, T. Maruyama, M. Goto, Design of a specific peptide tag that affords covalent and site-specific enzyme immobilization catalyzed by microbial transglutaminase. Biomacromolecules, 6, 2299-2304 (2005).
  11. K Nakashima, F. Kubota, T. Maruyama, M. Goto, Feasibility of ionic liquids as alternative separation media for industrial solvent extraction processes. Ind Eng Chem Res, 44, 4368 - 4372 (2005).
  12. J. Michizoe, H. Ichinose, N. Kamiya, T. Maruyama, M. Goto, Biodegradation of phenolic environmental pollutants by a surfactant-laccase complex in organic media. J. Biosci. Bioeng. 99, 642-647 (2005).
  13. E. Miyako, T. Maruyama, F. Kubota, N. Kamiya, M. Goto, Optical resolution of various amino acids using a supported liquid membrane encapsulating a surfactant-protease complex. Langmuir 20, 5564-5568 (2005).
  14. K. Araki, T. Maruyama, N. Kamiya, M. Goto, Metal ion-selective membrane prepared by surface molecular imprinting. J. Chromatogr. B 818, 141-145 (2005).
  15. T. Maruyama, T. Takata, H. Ichinose, N. Kamiya, H Kuma, N Hamasaki, H Morita and M. Goto, Detection of point mutations in the HBV polymerase gene using a fluorescence intercalator in reverse micelles, Biotechnol Prog, 21, 575-579 (2005).
  16. J. Michizoe, H. Ichinose, N. Kamiya, T. Maruyama, M. Goto, Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil Emulsions. J. Biosci. Bioeng., 99, 12-17 (2005).
  17. E. Miyako, T. Maruyama, N. Kamiya, M. Goto, A supported liquid membrane encapsulating a surfactant-lipase complex for selective separation of organic acids. Chem. Eur. J. 11, 1163-1170 (2005).
  18. L.C. Park, T. Maruyama, N. Kamiya, M. Goto, H. Kuma, and N. Hamasaki, Mutation detection in the drug-resistant hepatitis B virus polymerase gene using nanostructured reverse micelles. Anal. Sci., 20, 1609-1611(2004).
  19. M. Sakono, Y. Kawashima, H. Ichinose, T. Maruyama, N. Kamiya, M. Goto, Direct refolding of inclusion bodies using reversed micelles. Biotechnol. Prog., 20, 1783-1787 (2004).
  20. T. Maruyama, T. Kaji, T. Ohkawa, K. Sotowa, H. Matsushita, F. Kubota, N. Kamiya, K. Kusakabe, M. Goto, Intermittent partition walls promote solvent extraction of metalions in a microfluidic device. Analyst 129, 1008-1013 (2004).
  21. E. Miyako, T. Maruyama, N. Kamiya, and M. Goto, Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex. J. Am. Chem. Soc., 126, 8622-8623 (2004).
  22. T. Maruyama, H. Matsushita, J. Uchida, F. Kubota, N. Kamiya, M. Goto, Liquid membrane operations in a microfluidic device for selective separation of metal ions. Anal. Chem., 76, 4495-4500 (2004).
  23. 都英次郎、丸山達生、神谷典穂、後藤雅宏、有機酸の選択的分離が可能なリパーゼ-オルガノゲル膜システムの開発、膜 (Membrane)、29, 236-243 (2004).
  24. 迫野昌文、河嶋優美、一瀬博文、丸山達生、神谷 典穂、後藤雅宏、逆ミセルによるインクルージョンボディの高効率リフォールディング、化学工学論文集, 30, 468-473 (2004).
  25. J. Tominaga, J. Michizoe, N. Kamiya, H. Ichnose, T. Maruyama, M. Goto. Factors affecting oxidative activiy of hydroxyl group of laccase towards biphenyl derivatives in a homogeneous aqueous-nonaqueous systems. J. Biosci. Bioeng., 98, 14-19 (2004).
  26. H. Ichinose, J. Michizoe, T. Maruyama, N. Kamiya, and M. Goto, Electron transfer reactions and functionalization of cytochrome P450cam monooxygenase system in reverse Micelles. Langmuir, 20, 5564-5568 (2004).
  27. T. Maruyama, H. Yamamura, T. Kotani, N. Kamiya, M. Goto, Poly(ethylene glycol)-lipase complex highly active and enantioselective in ionic liquids. Org. Biomol. Chem., 2, 1239-1244 (2004).
  28. M. Sakono, T. Maruyama, N. Kamiya and M. Goto, Refolding of denatured carbonic anhydrase B by reversed micelles formulated with nonionic surfactant. Biochem. Eng. J., 19, 217-220 (2004).
  29. T. Maruyama, T. Kotani, H. Yamamura, N. Kamiya, and M. Goto, Poly(ethylene glycol)-lipase complexes catalytically-active in fluorous solvents. Org. Biomol. Chem., 2, 524-527 (2004).
  30. 丸山達生、内田純一、大川朋裕、久保田富生子、神谷典穂、後藤雅宏、マイクロ流体デバイスを用いたオリゴペプチドの固相合成，化学工学論文集、30, 180-182 (2004).
  31. J. Michizoe, Y. Uchimura, H. Ichinose, T. Maruyama, N. Kamiya, H. Wariishi, S. Furusaki, M. Goto, Activation of manganese peroxidase in an organic medium using a mediator. Biochem Eng J, 19, 43-46 (2004).
  32. T. Maruyama, L.-C. Park, T. Shinohara, M. Goto, DNA hybridization in nanostructural molecular assemblies enables detection of gene mutations without a fluorescent probe. Biomacromolecules, 5, 49-53 (2004).
  33. E. Miyako, T. Maruyama, N. Kamiya, and M. Goto, Enantioselective transport of (S)-ibuprofen through a lipase-facilitated supported liquid membrane based on ionic liquids. Chem Commun, (23) 2926-2927 (2003).
  34. T. Maruyama, J. Uchida, T. Ohkawa, T. Futami, K. Katayama, K. Nishizawa, K. Sotowa, F. Kubota, N. Kamiya, M. Goto, Enzymatic degradation of p-chlorophenol in a two-phase flow microchannel system. Lab on a Chip, 3, 315-319 (2003).
  35. T. Maruyama, T. Takata, H. Ichinose, L.C. Park, N. Kamaiya, M. Goto, Simple detection of point mutations in DNA oligonucleotides using SYBR Green I. Biotechnol. Lett. 25, 1637-1641 (2003).
  36. K. Nakashima, F. Kubota, T. Maruyama, M. Goto, Ionic Liquids as a Novel Solvent for Lanthanide Extraction. Anal. Sci., 19, 1097-1098 (2003).
  37. E. Miyako, T. Maruyama, N. Kamiya, M. Goto, Lipase-catalyzed reactions drive transport of organic acids through a supported liquid membrane. J. Biosci. Bioeng. 96, 370-374 (2003).
  38. 道添純二、小谷貴浩、富永譲、丸山達生、一瀬博文、神谷典穂、後藤雅宏、ナノ集合体を利用した有機溶媒中におけるマンガンペルオキシダーゼの機能発現と環境汚染物質の分解、膜 (Membrane)、28、191-197 (2003).
  39. S.K. Khare, T. Maruyama, T.M. Kuo, M. Nakajima, Modification of Chromobacterium viscosum lipase by stearic acid. J. Plant Biochem. Biotechnol., 12, 73-76 (2003).
  40. E. Miyako, T. Maruyama, N. Kamiya, M. Goto, Use of ionic liquids in a lipase-facilitated supported liquid membrane. Biotechnol. Lett. 25, 805-808 (2003).
  41. T. Maruyama, M. Nakajima, H. Kondo, K. Kawasaki, M. Seki M. Goto, Can Lipases Hydrolyze Peptide Bond? Enz. Microb. Technol. 32, 655-657 (2003).
  42. J. Michizoe, Y. Uchimura, T. Maruyama, N. Kamiya, M. Goto, Control of water content by reverse micellar solutions for peroxidase catalysis in a water-immiscible organic solvent. J. Biosci. Bioeng. 95, 425-427 (2003).
  43. L.-C. Park, T. Maruyama, M. Goto, DNA hybridization in reverse micelles and its application to mutation detection. Analyst, 128, 161-165 (2003).
  44. T. Maruyama, S. Noda, N. Kamiya, M. Goto, Ring-opening polymerization of lactones catalyzed by surfactant-coated lipases in organic solvents. J Chem Eng Jpn, 36, 307-312 (2003).
  45. M. Yasuno, M. Nakajima, S. Iwamoto, T. Maruyama, S. Sugiura, I. Kobayashi, A. Shono, K. Satoh, Visualization and characterization of SPG membrane emulsification. J. Membr. Sci. 210, 29-37 (2002).
  46. 道添純二、篠原謙治、丸山達生、草壁克己、後藤雅宏、環境汚染物質の分解を目的としたマイクロバイオリアクターの開発、化学工学論文集、29、82-86 (2003).
  47. T. Maruyama, S. Nagasawa, M. Goto, Enzymatic synthesis of sugar amino acid esters in organic solvents. J. Biosci. Bioeng. 94, 357-361 (2002).
  48. T. Maruyama, S. Nagasawa, M. Goto, Polyethylene glycol-lipase complex catalytically active in ionic liquid. Biotechnol. Lett. 24, 1341-1345 (2002).
  49. T. Maruyama, S. Umezaki, M. Nakajima, M. Seki, Interesterification and hydrolysis reactions catalyzed by fatty acid-modified lipases. Euro. J. Lipid Sci. Technol. 104, 255?261 (2002).
  50. T. Maruyama, M. Nakajima, M. Seki, Effect of hydrocarbon-water interfaces on synthetic and hydrolytic activity of lipases. J. Biosci. Bioeng., 92, 242-247 (2001).
  51. T. Maruyama, S. Katoh, M. Nakajima, H. Nabetani, A. Shono, K. Satoh, FT-IR Analysis of BSA Fouled on Microfiltration and Ultrafiltration Membranes, J. Membr. Sci., 192, 201-207 (2001).
  52. T. Maruyama, S. Katoh, M. Nakajima, H. Nabetani, Mechanism of BSA aggregation during ultrafiltration., Biotechnol. Bioeng., 75, 233-238 (2001).
  53. T. Maruyama, M. Nakajima, S. Ichikawa, S. Furusaki, M. Seki, Structural study of lipase modified with fatty scids, Biochem. Eng. J., 9, 185-191 (2001).
  54. T. Maruyama, M. Nakajima, S. Ichikawa, Y. Sano, H. Nabetani, S. Furusaki, M. Seki, Small?angle x-ray scattering analysis of stearic acid modified lipase, Biosci. Biotech. Biochem., 75, 1003-1006 (2001).
  55. T. Maruyama, M. Nakajima, S. Ichikawa, H. Nabetani, S. Furusaki, M. Seki, Oil-water interfacial activation of lipase for interesterification of triglyceride and fatty acid. J. Am. Oil Chem. Soc., 77, 1121-1126 (2000).

解説

  1. 丸山達生、後藤雅宏、ナノ集合体逆ミセルを用いた遺伝子診断、化学工業、Vol 55, No. 4, 263-267(2004).
  2. 後藤雅宏、久保田富生子、丸山達生、選択的分離技術としての液膜法の新展開、ケミヤカルエンジニヤリング、48、49-55 (2003).
  3. 後藤雅宏、神谷典穂、丸山達生、非水系での生体触媒反応プロセスの構築、最近の化学工学54, 45-62 (2002)
  4. 丸山　達生、中嶋　光敏、関　実、脂質修飾による酵素の活性化とその応用、科学と工業、74, 15-19 (2000).

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